To what does the "solitude" of the title refer?

Why is Jose Arcadio's death made comic (pp. 131-2)?

What is the meaning of the plague of insomnia? What brings it on?

What's with all the little gold fishes?

Does time in Macondo go in a circle, or backward, or forward?

What is intended by the return of several characters (Melquiades, Jose Arcadio Buendia, Prudencio Aguilar) from the dead?

Is Macondo a lost paradise?

What advantage is there to the confusing profusion of similar names (Jose, Arcadio, Remedios, et al.)?

Is Melquiades the author of One Hundred Years of Solitude?